Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring.

ABSTRACT:

Objective

Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This study was designed to address this gap in knowledge.

Methods

Maternal anxiety, stress, and depression were assessed at multiple time points during pregnancy in two independent low-risk mother-infant cohorts (N=115 and N=2,156). Trajectories in maternal stress levels in relation to infant negative affect were examined in both cohorts. Neonatal amygdala resting-state functional connectivity MRI was examined in a subset of one cohort (N=60) to explore the potential relationship between maternal stress trajectories

SUBMITTER: Marr MC 

PROVIDER: S-EPMC11646109 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature