Pharmacokinetic Profiling of Unlabeled Magnetic Nanoparticles Using Magnetic Particle Imaging as a Novel Cold Tracer Assay.

ABSTRACT: We present a magnetic particle imaging (MPI)-based assay for calculating the blood half-life and tissue uptake of magnetic nanoparticles (MNPs) without the need of labeling them. Dual-catheterized rats received 2.0 mg Fe of Synomag^®-D70, Synomag^®-D50, ferucarbotran, and Feraheme^® by femoral vein injection. The MPI signal of blood samples drawn from the femoral artery at various time points was then measured. Synomag^®-D70 exhibited biexponential clearance with half-lives of 3.2 and 31.2 min, Synomag^®-D50 a monoexponential clearance (t_1/2 = 11.4 min), ferucarbotran a biexponential clearance (t_1/2 = 2.4 and 10.8 min), and Feraheme^® a biexponential clearance (t_1/2 = 60.9 and

SUBMITTER: Salimi M 

PROVIDER: S-EPMC11646110 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature