Oxidative stress as a potential mechanism linking gestational phthalates exposure to cognitive development in infancy.

ABSTRACT:

Background

Gestational exposure to phthalates, endocrine disrupting chemicals widely used in consumer products, has been associated with poor recognition memory in infancy. Oxidative stress may represent one pathway linking this association. Hence, we examined whether exposure to phthalates was associated with elevated oxidative stress during pregnancy, and whether oxidative stress mediates the relationship between phthalate exposure and recognition memory.

Methods

Our analysis included a subset of mother-child pairs enrolled in the Illinois Kids Development Study (IKIDS, N = 225, recruitment years 2013-2018). Concentrations of 12 phthalate metabolites were quantified in 2nd trimester urine samples. Four oxidative stress biomarkers (8-isoprostane-PGF_2α, 2,3-dinor-

SUBMITTER: Ortlund KE 

PROVIDER: S-EPMC11646183 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature