Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Despite advances in diagnosis and treatment, including surgery, chemotherapy, and immunotherapy, accurate clinical markers are still lacking. The development of prognostic and predictive indicators, particularly in the context of personalized medicine, could significantly improve CRC patient management.

Method

In this retrospective study, we used FFPE blocks of tissue samples from CRC patients at Augusta University (AU) to quantify a custom 15-gene panel. To differentiate the tumor and adjacent normal regions (NAT), H&E staining was utilized. For the quantification of transcripts, we used the NanoString nCounter platform. Kaplan-Meier and Log-rank tests were used to pe

SUBMITTER: Ahluwalia P 

PROVIDER: S-EPMC11646222 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature