Revealing the causal relationship between thyroidectomy, thyroid function status, and eczema: a bidirectional two-sample Mendelian Randomization study.

ABSTRACT: This Mendelian Randomization (MR) study aims to explore the potential bidirectional causal relationship between thyroidectomy, thyroid function status, and eczema. We utilized summary statistics from genome-wide association studies of European ancestry for thyroidectomy (4360 cases and 458,573 controls), hyperthyroidism (2547 cases and 334,612 controls), and hypothyroidism (337,199 samples), employing genetic instruments to investigate their association with eczema (461,199 samples), and vice versa. Primary causal estimates were obtained using the inverse variance weighting method (IVW), with a series of sensitivity analyses conducted to assess the robustness of the results. The study found that genetically predicted thyroidectomy has a negative effect on eczema (OR = 0.645; 95% CI 0.498-0

SUBMITTER: Yin Y 

PROVIDER: S-EPMC11646262 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature