Fabrication and in vivo testing of a sub-mm duckbill valve for hydrocephalus treatment.

ABSTRACT: Hydrocephalus is characterized by the accumulation of excess cerebrospinal fluid (CSF) in the cranium due to an imbalance between production and absorption of CSF. The standard treatment involves the implantation of a shunt to divert excess CSF into the peritoneal cavity, but these shunts exhibit high failure rates over time. In pursuit of improved reliability and performance, this study proposes a miniaturized valve designed to mimic the natural one-way valve function of the arachnoid granulations and thereby replace the shunts. A benchtop testing setup was employed to characterize the behavior of the fabricated valve. Additionally, an animal study was conducted to assess the valve's in vivo performance. This involved the injection of saline into the lateral ventricle to elevate intracran

SUBMITTER: Jung Y 

PROVIDER: S-EPMC11646279 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature