Evolution of CEACAM pathogen decoy receptors in primates.

ABSTRACT:

Background

CEACAM1 in leukocytes controls cell activation during inflammation. This and its expression in epithelial cells led to frequent independent appropriation of CEACAM1 as receptor by pathogens in humans and other species to gain host access and to downregulate its immune response. As a countermeasure, decoy receptors with CEACAM1-like pathogen-binding domains evolved. The granulocyte-specific human CEACAM3 endocytic receptor diverts CEACAM1-binding pathogens to neutrophils for internalization and destruction. The role of the glycosylphosphatidylinositol-anchored CEACAM5 and CEACAM6 which can also bind CEACAM1-targeting pathogens in humans is less clear.

Methods

We analyzed the selection of CEACAMs to avoid pathogen binding and to maintain similarity between pathogen

SUBMITTER: Zimmermann W 

PROVIDER: S-EPMC11646289 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature