Dengue NS1 Antibodies Are Associated With Clearance of Viral Nonstructural Protein-1.

ABSTRACT:

Background

Dengue vascular permeability syndrome is the primary cause of death in severe dengue infections. The protective versus potentially pathogenic role of dengue nonstructural protein-1 (NS1) antibodies are not well understood. The main goal of this analysis was to characterize the relationship between free NS1 concentration and NS1 antibody titers in primary and secondary dengue infection to better understand the presence and duration of NS1 antibody complexes in clinical dengue infections.

Methods

Hospitalized participants with acute dengue infection were recruited from Northern Colombia between 2018 and 2020. Symptom assessment, including dengue signs and symptoms, chart review, and blood collection, was performed. Primary versus secondary dengue was assessed serolo

SUBMITTER: Premazzi Papa M 

PROVIDER: S-EPMC11646586 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature