Viral Genomic Variation and the Severity of Genital Herpes Simplex Virus-2 Infection as Quantified by Shedding Rate: A Viral Genome-Wide Association Study.

ABSTRACT:

Background

The clinical severity of genital herpes simplex virus-2 (HSV-2) infection varies widely among infected persons with some experiencing frequent genital lesions while others are asymptomatic. The viral genital shedding rate is closely associated with, and has been established as, a surrogate marker of clinical severity.

Methods

To assess the relationship between viral genetics and shedding, we assembled a set of 145 persons who had the severity of their genital herpes quantified through determination of their HSV genital shedding rate. An HSV-2 sample from each person was sequenced and biallelic variants among these genomes were identified.

Results

We found no association between metrics of genome-wide variation in HSV-2 and shedding rate. A viral genome-wide

SUBMITTER: Casto AM 

PROVIDER: S-EPMC11646587 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature