A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections.

ABSTRACT:

Background

Our goal was to identify genetic and modifiable risk factors for upper urinary tract infections (UTIs).

Methods

We used data from UK Biobank, the Trøndelag Health Study, and the Michigan Genomics Initiative to conduct genome-wide association studies and sex-stratified analyses on upper UTI. Mendelian randomization (MR) analyses were conducted to examine potential causal relationships between cardiometabolic risk factors and upper UTIs.

Results

One genome-wide significant (P ≤ 5E-08) locus was associated with the susceptibility to upper UTI, located near TSN in the female-only analysis. Additionally, we identified suggestive (P ≤ 5E-06) loci near DNAI3 for females, SCAMP1-AS1 for males, and near TSN, LINC00603, and HLA-DQA2 for both sexes. In MR analyses, hi

SUBMITTER: Flatby HM 

PROVIDER: S-EPMC11646603 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature