The Genetic Diversity of Nipah Virus Across Spatial Scales.

ABSTRACT:

Background

Nipah virus (NiV), a highly lethal virus in humans, circulates in Pteropus bats throughout South and Southeast Asia. Difficulty in obtaining viral genomes from bats means we have a poor understanding of NiV diversity.

Methods

We develop phylogenetic approaches applied to the most comprehensive collection of genomes to date (N = 257, 175 from bats, 73 from humans) from 6 countries over 22 years (1999-2020). We divide the 4 major NiV sublineages into 15 genetic clusters. Using Approximate Bayesian Computation fit to a spatial signature of viral diversity, we estimate the presence and the average size of genetic clusters per area.

Results

We find that, within any bat roost, there are an average of 2.4 co-circulating genetic clusters, rising to 5.5 clusters at

SUBMITTER: Cortes-Azuero O 

PROVIDER: S-EPMC11646605 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature