Genomic Diversity and Antimicrobial Susceptibility of Invasive Neisseria meningitidis in South Africa, 2016-2021.

ABSTRACT:

Background

Invasive meningococcal isolates in South Africa have in previous years (<2008) been characterized by serogroup B, C, W, and Y lineages over time, with penicillin intermediate resistance (peni) at 6%. We describe the population structure and genomic markers of peni among invasive meningococcal isolates in South Africa, 2016-2021.

Methods

Meningococcal isolates were collected through national, laboratory-based invasive meningococcal disease (IMD) surveillance. Phenotypic antimicrobial susceptibility testing and whole-genome sequencing were performed, and the mechanism of reduced penicillin susceptibility was assessed in silico.

Results

Of 585 IMD cases reported during the study period, culture and PCR-based capsular group was determined for 477/585 (82%); and

SUBMITTER: Mikhari RL 

PROVIDER: S-EPMC11646611 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature