Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil.

ABSTRACT:

Background

Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB so that therapy can be targeted. We evaluated host blood transcriptomic signatures for progression to TB disease.

Methods

Close contacts (≥4 hours of exposure per week) of adult patients with culture-confirmed pulmonary TB were enrolled in Brazil. Investigation for incident, microbiologically confirmed, or clinically diagnosed pulmonary or extrapulmonary TB disease through 24 months of follow-up was symptom triggered. Twenty previously validated blood TB transcriptomic signatures were measured at baseline by real-time quantitative polymerase chain

SUBMITTER: Mendelsohn SC 

PROVIDER: S-EPMC11646616 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature