Hypothalamic obesity: Epidemiology in rare sellar/suprasellar tumors-A German claims database analysis.

ABSTRACT: Hypothalamic obesity (HO) is defined as abnormal weight gain resulting in severe persistent obesity due to physical, tumor- and/or treatment-related damage to the hypothalamus. HO epidemiology is poorly understood. We developed a database algorithm supporting the standardized identification of tumor/treatment-related HO (TTR-HO) patients. The algorithm is used to estimate incidence rates of TTR-HO patients in the German healthcare context from a representative claims database (n = 5.42 million) covering 2010-2020. Patients were identified based on surgery/radiotherapy procedures and HO-associated tumor diagnoses (n = 3976). HO was defined by incident obesity and validated based on incident diabetes insipidus diagnoses and desmopressin prescription within a 12-month period after surgery/rad

SUBMITTER: Witte J 

PROVIDER: S-EPMC11646665 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature