Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores.

ABSTRACT:

Objective

This study aims to evaluate the utility of polygenic risk scores (PRS) in women with early menopause (EM) and to investigate the clinical characteristics and risk factors associated with EM based on genetic risk.

Study design

Genotyping data and clinical data from women with EM and women with normal age of menopause retrieved from UK Biobank were used for early menopause risk prediction model establishment. Subsequently, 99 women diagnosed with EM and 1027 control women underwent PGT-M were recruited for model validation from across eight hospitals in China. According to PRS percentiles, these participants were further classified into high risk and intermediate risk groups. Characteristics among women at different risk levels were compared, and risk factors with ea

SUBMITTER: Zhong W 

PROVIDER: S-EPMC11646720 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature