Prediction of protein interactions between pine and pine wood nematode using deep learning and multi-dimensional feature fusion.

ABSTRACT: Pine Wilt Disease (PWD) is a devastating forest disease that has a serious impact on ecological balance ecological. Since the identification of plant-pathogen protein interactions (PPIs) is a critical step in understanding the pathogenic system of the pine wilt disease, this study proposes a Multi-feature Fusion Graph Attention Convolution (MFGAC-PPI) for predicting plant-pathogen PPIs based on deep learning. Compared with methods based on single-feature information, MFGAC-PPI obtains more 3D characterization information by utilizing AlphaFold and combining protein sequence features to extract multi-dimensional features via Transform with improved GCN. The performance of MFGAC-PPI was compared with the current representative methods of sequence-based, structure-based and hybrid characteriz

SUBMITTER: Wang L 

PROVIDER: S-EPMC11646721 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature