PLEK2: a potential biomarker for metastasis and prognostic evaluation in uveal melanoma.

ABSTRACT:

Background

Uveal melanoma (UVM) is an aggressive tumor known for its high metastatic rate, making it necessary to delineate potential molecules that may promote the development of UVM. PLEK2 has been found to promote the progression and metastasis of some tumors, but its role in UVM has not yet been reported. Through this study, we hope to explore the effect of PLEK2 on the prognosis of UVM patients and to discover the potential functional role and intrinsic mechanism of PLEK2.

Methods

The GEO datasets GSE211763 and GSE149920 were analyzed using GEO2R to identify differentially expressed genes that may be associated with UVM progression and metastasis. A Protein-Protein Interaction Network (PPI) was constructed to identify key molecules. The correlation between PLEK2 express

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11646761 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature