Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models.

ABSTRACT: Sensitivity analyses are important components of physiologically based pharmacokinetic (PBPK) model development and are required by regulatory agencies for PBPK submissions. They assess the impact of parametric uncertainty and variability on model estimates, aid model optimization by identifying parameters requiring calibration, and enable the testing of assumptions within PBPK models. One-at-a-time (OAT) sensitivity analyses quantify the impact on a model output in response to changes in a single parameter while holding others fixed. Global sensitivity analysis (GSA) methods provide more comprehensive assessments by accounting for changes in all uncertain or variable parameters, though at a higher computational cost. This tutorial article presents a software package for conducting both OA

SUBMITTER: Najjar A 

PROVIDER: S-EPMC11646943 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature