Quantitative systems toxicology modeling in pharmaceutical research and development: An industry-wide survey and selected case study examples.

ABSTRACT: Quantitative systems toxicology (QST) models are increasingly being applied for predicting and understanding toxicity liabilities in pharmaceutical research and development. A European Federation of Pharmaceutical Industries and Associations (EFPIA)-wide survey was completed by 15 companies. The results provide insights into the current use of QST models across the industry. 73% of responding companies with more than 10,000 employees utilize QST models. The most applied QST models are for liver, cardiac electrophysiology, and bone marrow/hematology. Responders indicated particular interest in QST models for the central nervous system (CNS), kidney, lung, and skin. QST models are used to support decisions in both preclinical and clinical stages of pharmaceutical development. The survey sugg

SUBMITTER: Beattie KA 

PROVIDER: S-EPMC11646944 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature