Metabolic response of Klebsiella oxytoca to ciprofloxacin exposure: a metabolomics approach.

ABSTRACT:

Introduction

Rapid detection and identification of pathogens and antimicrobial susceptibility is essential for guiding appropriate antimicrobial therapy and reducing morbidity and mortality associated with sepsis.

Objectives

The metabolic response of clinical isolates of Klebsiella oxytoca exposed to different concentrations of ciprofloxacin (the second generation of quinolones antibiotics) were studied in order to investigate underlying mechanisms associated with antimicrobial resistance (AMR).

Methods

Metabolomics investigations were performed using Fourier-transform infrared (FT-IR) spectroscopy as a metabolic fingerprinting approach combined with gas chromatography-mass spectrometry (GC-MS) for metabolic profiling.

Results

Our findings demonstrated that met

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC11646952 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature