Genomic mosaicism in colorectal cancer and polyposis syndromes: a systematic review and meta-analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) and polypoid syndromes are significant public health concerns, with somatic mosaicism playing a crucial role in their genetic diversity. This study aimed to investigate the prevalence and impact of somatic mosaicism in these conditions.

Methods

A search was conducted using PubMed, Scopus, and Web of Sciences to identify studies evaluating mosaicism in patients with CRC or polyposis syndromes. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine prevalence rates. Statistical analyses were performed using R software 4.3.

Results

A total of 27 studies, encompassing 2272 patients, were included in the analysis. Of these, 108 patients exhibited somatic mosaicism, resulting in an overall prevalence of 8.79% (9

SUBMITTER: de Moraes FCA 

PROVIDER: S-EPMC11646957 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature