Fatty acid traits mediate the effects of uric acid on cancers: a Mendelian randomization study.

ABSTRACT:

Introduction

Previous findings on the association between uric acid (UA) levels and cancer risk are conflicting. Moreover, the mechanisms underlying the interactions between UA levels, fatty acid traits, and cancer outcomes remain complex; it is still unclear whether elevated UA levels influence fatty acid traits and, thereby, contribute to an increased cancer risk. Therefore, we aimed to investigate the association between UA levels and cancer risk, with a specific focus on the potential mediating role of fatty acid traits.

Methods

We employed a Mendelian randomization (MR) analysis utilizing genetic data from large-scale genome-wide association studies to assess the causal relationships among UA levels, fatty acid traits, and cancer risk. The primary method used was the in

SUBMITTER: Li J 

PROVIDER: S-EPMC11646984 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature