Genotypes and drug resistance pattern of <i>Mycobacterium tuberculosis</i> complex among clinically diagnosed pulmonary tuberculosis patients.

ABSTRACT:

Background

Clinically diagnosed pulmonary tuberculosis (TB) (CDPTB) patients account for a huge proportion of TB. However, little is known about the genetic diversity and drug resistance profile of Mycobacterium tuberculosis Complex (MTBC) strains in this group of patients.

Method

Unmatched case-control study was conducted among 313 PTB patients to compare the genetic diversity of MTBC and their drug resistance profiles among CDPTB (n = 173) and bacteriologically confirmed pulmonary TB (BCPTB) (n = 140) patients. Lowenstein-Jensen (LJ) culture, geneXpert and acid fast staining were performed on sputum specimen collected from both CDPTB and BCPTB patients. Spoligotyping, whole genome sequencing (WGS) and phenotypic drug resistance testing (DST) were done

SUBMITTER: Alemayehu A 

PROVIDER: S-EPMC11646991 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature