Molecular profiling of head and neck squamous cell carcinomas in North-eastern Italy identifies possible tumour cell vulnerabilities.

ABSTRACT:

Background and purpose

Head and Neck Squamous Cell Cancer (HNSCC) originates from the oral cavity, oropharynx, hypopharynx and larynx, and it ranks sixth among global cancers. Despite modest 5-year survival gains, the integration of molecular personalization lags behind and there is an urgent need to develop novel therapies and biomarkers.

Material and methods

This study outlined the somatic mutational profile of 15 HNSCC-enriched genes in a case series from North-eastern Italy, the region with the highest national HNSCC incidence. We conducted a comparative analysis with prior case studies and assessed the prognostic implications of the mutations that we found in these genes.

Results

Consistent with previous studies, oral cavity tumours showed a lower gene mutation f

SUBMITTER: Schiappacassi M 

PROVIDER: S-EPMC11647078 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature