Spatially Fractionated Radiation Therapy for Palliation in Patients With Large Cancers: A Retrospective Study.

ABSTRACT:

Purpose

Spatially fractionated radiation therapy (SFRT) is an irradiation technique developed to improve large cancer response. Although preliminary studies report highly positive results, data are still limited. The aim of this retrospective monocentric study was to investigate SFRT safety and activity.

Methods and materials

We analyzed all patients who underwent SFRT as a palliative treatment for large solid extracranial cancer (>4.5 cm) at our institution. The primary endpoint was objective response rate assessment at 3 months. Additionally, patients' antalgic response, target volume reduction, and performance status modification were measured. Toxicity data were recorded.

Results

From November 2021 to August 2023, 20 consecutive patients (20 lesions) underwent SFR

SUBMITTER: Iori F 

PROVIDER: S-EPMC11647081 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature