Effect of preconception antibiotics exposure on female reproductive health and pregnancy outcomes: a systematic review and meta-analysis.

ABSTRACT:

Background

The preconception period is a window of opportunity to influence maternal and pregnancy outcomes. Inappropriate use of antibiotics results in gut dysbiosis and may affect host reproductive health through multiple dimensions. Animal studies demonstrate that antibiotic treatment profoundly affects ovarian functions and the estrous cycle, and it has a direct implication for infertility. Infertility was defined as the inability to conceive after 12 months of unprotected intercourse. However, whether antibiotic exposure in the preconception period influences female fertility, miscarriage, and congenital malformation remains obscure and controversial.

Methods

A systematic review and meta-analysis until April 20, 2024, was conducted by searching PubMed, Web of Science, S

SUBMITTER: Alemu BK 

PROVIDER: S-EPMC11647117 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature