Genomic Landscape of ctDNA and Real-World Outcomes in Advanced Endometrial Cancer.

ABSTRACT:

Purpose

ctDNA is a novel technique extensively studied in solid tumors, although not currently well defined in endometrial cancer.

Experimental design

A de-identified retrospective analysis of 1,988 patients with advanced/recurrent endometrial cancer was performed. In addition, an analysis of a real-world evidence cohort was completed (n = 1,266). Patients underwent ctDNA testing using Guardant360 during routine clinical care. The objective was to describe and assess molecular landscape using ctDNA.

Results

Among 1,988 ctDNA samples, at least one somatic alteration was detected in 91.6% (n = 1,821). Most frequently altered genes were TP53 (64%), PIK3CA (29%), PTEN (25%), ARID1A (20%), and KRAS (14%). Overall, 18.5% had amplifications, with the majority identified in C

SUBMITTER: Soberanis Pina P 

PROVIDER: S-EPMC11647206 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature