White matter integrity and cognitive performance in the subacute phase after ischemic stroke in young adults.

ABSTRACT:

Introduction

Reduced white matter integrity outside the stroke lesion may be a potential contributor of post-stroke cognitive impairment. We aimed to investigate how a stroke lesion affects the integrity of surrounding white matter, and whether the integrity of the non-lesioned part of white matter tracts is associated with cognitive performance after ischemic stroke in young adults.

Methods

Patients from the ODYSSEY study, aged 18-49 years, with a first-ever ischemic stroke, underwent 3T MRI and cognitive assessment within six months after the index event. Using TractSeg and free water imaging, we analyzed free water corrected fractional anisotropy (FA_T), free water corrected mean diffusivity (MD_T), and free water (FW) of all white matter tracts outsid

SUBMITTER: Schellekens MMI 

PROVIDER: S-EPMC11647214 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature