Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration.

ABSTRACT: Bone is a richly innervated and vascularized tissue, whereas nerve-vascular network reconstruction was often ignored in biomaterial design, resulting in delayed or incomplete bone healing. Inspired by the bone injury microenvironments, here we report a controllable drug delivery strategy using a pH and reactive oxygen species (ROS) dual-response injectable hydrogel. Based on the dynamic borate ester bond covalent crosslinking, nano-hydroxyapatite (HA) and curculigoside (CCG) are integrated into PVA/TSPBA (PT) to construct a responsive injectable hydrogel (PTHC), which scavenges excessive ROS from the injury microenvironment and responsively releases HA and CCG, providing favorable homeostasis and in situ sustained release drug delivery system for bone repair. Additionally, PTHC hydr

SUBMITTER: Wang W 

PROVIDER: S-EPMC11647231 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature