Genetic variation in circadian regulator gene <i>BMAL1</i> in psychiatric, psychological and cardiometabolic traits: a trans-ancestry UK Biobank study.

ABSTRACT:

Background

The link between cardiometabolic disease and mental illness has been well established but remains incompletely explained. One hypothesis suggests that circadian rhythm dysregulation links cardiometabolic disease and mental illnesses. BMAL1 is a circadian rhythm regulatory gene. Human genetic studies have implicated BMAL1 in depression, schizophrenia, bipolar disorder as well as body mass index, blood pressure and lipid levels.

Objective

We investigated the BMAL1 locus genetic variants for associations with both cardiometabolic and mental illness.

Methods

Genetic and phenotypic data from UK Biobank (~500 000 participants) of White British, African-Caribbean, South Asian, white European and Multiple ancestries were used. Regression analys

SUBMITTER: Daudali H 

PROVIDER: S-EPMC11647332 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature