Elucidating the bidirectional association between autoimmune diseases and depression: a systematic review and meta-analysis.

ABSTRACT:

Question

Collective evidence for the bidirectional association between depression and autoimmune diseases (ADs) is scarce, especially for subgroups of patients with specific ADs. We conducted a meta-analysis to determine the incidence rates and relative risks (RRs) of depression among patients with ADs, and vice versa.

Study selection and analysis

PubMed, Embase, Web of Science, Ovid, PsycNet and Cochrane were searched up to 10 September 2024. Cohort studies evaluating longitudinal risks between ADs and depression were included. Incidence rates and RRs of depression among patients with ADs and vice versa were pooled.

Findings

The analysis included 47 studies, involving over 40.77 million participants. The pooled incidence rate of depression among patients with ADs was

SUBMITTER: Li Y 

PROVIDER: S-EPMC11647340 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature