Association between birth weight and chronic obstructive pulmonary disease in the UK Biobank: a prospective cohort study.

ABSTRACT:

Background

Birth weight has been reported to be associated with chronic obstructive pulmonary disease (COPD) in adulthood, but the results have not yet been determined. This study aims to analyse the potential association of birth weight with COPD risk in UK Biobank.

Methods

We conducted a prospective analysis for participants without baseline COPD in UK Biobank. The HRs and 95% CIs were calculated by multivariable Cox regression models, and dose-response relationship was evaluated by restricted cubic splines. Besides, we also calculated the interactions for covariates and further analysed the joint effects.

Results

A total of 251 172 participants with birth weight data were included in this study, and 5602 COPD cases were found during follow-up. According to Cox regr

SUBMITTER: Luo P 

PROVIDER: S-EPMC11647385 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature