Transition to seizure in focal epilepsy: From SEEG phenomenology to underlying mechanisms.

ABSTRACT:

Objective

For the pre-surgical evaluation of patients with drug-resistant focal epilepsy, stereo-electroencephalographic (SEEG) signals are routinely recorded to identify the epileptogenic zone network (EZN). This network consists of remote brain regions involved in seizure initiation. However, the pathophysiological mechanisms underlying typical SEEG patterns that occur during the transition from interictal to ictal activity in distant brain nodes of the EZN remain poorly understood. The primary aim is to identify and explain these mechanisms using a novel physiologically-plausible model of the EZN.

Methods

We analyzed SEEG signals recorded from the EZN in 10 patients during the transition from interictal to ictal activity. This transition consisted of a sequence of periods

SUBMITTER: Kayabas MA 

PROVIDER: S-EPMC11647430 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature