Matrix-assisted laser desorption/ionization mass spectrometry imaging as a new tool for molecular histopathology in epilepsy surgery.

ABSTRACT:

Objective

Epilepsy surgery is a treatment option for patients with seizures that do not respond to pharmacotherapy. The histopathological characterization of the resected tissue has an important prognostic value to define postoperative seizure outcome in these patients. However, the diagnostic classification process based on microscopic assessment remains challenging, particularly in the case of focal cortical dysplasia (FCD). Imaging mass spectrometry is a spatial omics technique that could improve tissue phenotyping and patient stratification by investigating hundreds of biomolecules within a single tissue sample, without the need for target-specific reagents.

Methods

An in situ proteomic technique called matrix-assisted laser desorption/ionization mass spectrometry imagin

SUBMITTER: Cagnoli C 

PROVIDER: S-EPMC11647443 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature