Association between coronary microvascular dysfunction and exercise capacity in dilated cardiomyopathy.

ABSTRACT:

Background

Aerobic exercise capacity is an independent predictor of mortality in dilated cardiomyopathy (DCM), but the central mechanisms contributing to exercise intolerance in DCM are unknown. The aim of this study was to characterize coronary microvascular function in DCM and determine if cardiovascular magnetic resonance (CMR) measures are associated with aerobic exercise capacity.

Methods

Prospective case-control comparison of adults with DCM and matched controls. Adenosine-stress perfusion CMR to assess cardiac structure, function and automated inline myocardial blood flow quantification, and cardiopulmonary exercise testing to determine peak VO₂ was performed. Pre-specified multivariable linear regression, including key clinical and cardiac variables, was u

SUBMITTER: Dattani A 

PROVIDER: S-EPMC11647499 | biostudies-literature | 2024 Winter

REPOSITORIES: biostudies-literature