Genetic Variants and Persistent Impairment Following Mild Traumatic Brain Injury: A Systematic Review.

ABSTRACT:

Objective

The purpose of this review is to systematically assess primary research publications on known genetic variants, which modify the risk for symptoms or dysfunction persisting 30 days or more following mild traumatic brain injury (mTBI).

Summary of review

A search of PubMed and Embase from inception through June 2022 identified 42 studies that associated genetic variants with the presence of symptoms or cognitive dysfunction 30 days or more following mTBI. Risk of bias was assessed for each publication using the Newcastle Ottawa Scale (NOS). Fifteen of the 22 studies evaluating apolipoprotein E ( APOE ) ɛ4 concluded that it was associated with worse outcomes and 4 of the 8 studies investigating the brain-derived neurotrophic factor ( BDNF ) reported the Val66Met allel

SUBMITTER: Feigen CM 

PROVIDER: S-EPMC11647579 | biostudies-literature | 2025 Jan-Feb 01

REPOSITORIES: biostudies-literature