Xenon anaesthesia is associated with a reduction in frontal electroencephalogram peak alpha frequency.

ABSTRACT:

Background

Administration of conventional anaesthetic agents is associated with changes in electroencephalogram (EEG) oscillatory dynamics, including a reduction in the peak alpha frequency. Computational models of neurones can reproduce such phenomena and are valuable tools for investigating their underlying mechanisms. We hypothesised that EEG data acquired during xenon anaesthesia in humans would show similar changes in peak alpha frequency and that computational neuronal models of recognised cellular actions of xenon would be consistent with the observed changes.

Methods

EEG recordings were obtained for 11 participants from a randomised controlled trial of xenon anaesthesia and for 21 participants from a volunteer study of xenon administration. The frontal peak alpha fre

SUBMITTER: McGuigan S 

PROVIDER: S-EPMC11647626 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature