IFN-α treatment may enable discontinuation of TKIs in NK cell-licensed patients with CML-CP.

ABSTRACT: The magnitude of the natural killer (NK) cell response contributes to the achievement of treatment-free remission (TFR) in patients with chronic myeloid leukemia (CML) and is regulated by the interaction between killer immunoglobulin-like receptors (KIRs) on NK cells and human leukocyte antigen (HLA) class I molecules on target cells. The abundant combination between KIR and HLA through genetic polymorphisms determines the functional diversity of NK cells. We previously reported that KIR3DL1-HLA-Bw status is associated with achievement of TFR by reflecting NK cell potential. Patients with strong interaction between KIR3DL1/HLA-Bw were identified as having a higher molecular relapse risk, based on the "missing self" hypothesis which suggests that the lack of cogn

SUBMITTER: Ureshino H 

PROVIDER: S-EPMC11647684 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature