Interleukin-6 transcripts up-regulation in lymph nodes from unicentric and multicentric Castleman disease.

ABSTRACT:

Introduction

Castleman disease (CD) represents a spectrum of heterogeneous lymphoproliferative disorders sharing peculiar histopathological features, clinically subdivided into unicentric CD (UCD) and multicentric CD (MCD) and presenting with variable inflammatory symptoms. Interleukin (IL)-6 and other cytokines play a major role in mediating CD inflammatory manifestations. Although the local microenvironment seems to be among the major sources of hypercytokinemia, the precise cellular origin of IL-6 production in CD is still debated.

Methods

A series of five nodal CD of different subtypes (one UCD, two idiopathic MCDs [iMCDs], one HIV-negative human herpesvirus 8 (HHV8)-associated MCD, and one HIV-positive HHV8-associated MCD) and a non-CD reactive control were tested using

SUBMITTER: Lucioni M 

PROVIDER: S-EPMC11647691 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature