Extramedullary disease in Waldenstrom macroglobulinemia: A population-based observational study.

ABSTRACT:

Introduction

Extramedullary disease (EMD) is a rare manifestation of Waldenström macroglobulinemia (WM), and its clinical and prognostic implications are poorly understood.

Methods

In this single-center study, we investigated the clinical significance of EMD in a cohort of 469 WM patients.

Results

EMD was identified in 30 (6.4%) patients, with the central nervous system, kidneys, and lungs being the most frequently affected sites. The cumulative incidence of EMD was 12.6% at 15 years. Median overall survival rates at 5 and 10 years for patients with EMD were 63% and 37%, respectively.

Conclusion

Our findings indicate a persistent risk of EMD throughout the disease course, with no significant impact on long-term survival.

SUBMITTER: Ostergaard S 

PROVIDER: S-EPMC11647728 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature