Sulfated Cellulose Nanofiber Hydrogel with Mucus-Like Activities for Virus Inhibition.

ABSTRACT: Mucus is the first defense barrier against viruses in the human immune system. Inspired by the mucus structure, we designed a highly sulfated hydrogel to bind viruses and prevent infection of the underlying cells. The hydrogel was formed by gelation of sulfated cellulose nanofiber (SCNF) with Ca²⁺. SCNF exhibited a mucin-like nanofiber structure with high numbers of sulfated groups. Based on the electrostatic interactions with a virus, SCNF could efficiently inhibit herpes simplex virus-1 (HSV-1) infection with a half-maximal inhibitory concentration (IC₅₀) of 0.43 μg/mL, which is comparable to that of heparin (IC₅₀ = 0.30 μg/mL). Benefiting from the multiporous structure and sulfate groups, the Ca²⁺-SCNF hydrogel could efficiently trap HSV-1 and

SUBMITTER: Long Y 

PROVIDER: S-EPMC11647751 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature