Preimplantation development analysis of aneuploid embryos with different chromosomal abnormalities.

ABSTRACT:

Background

The change of morphokinetic pattern in aneuploid embryos will facilitate the non-invasive selection of euploid embryos. In this study, we investigated the impact of different chromosomal abnormalities on the morphokinetic patterns of embryonic development.

Methods

Our cohort includes 939 time-lapse preimplantation genetic testing cycles performed between January 2019 and July 2022 at a single academic fertility center, with a total of 2876 biopsied blastocysts. Intracytoplasmic sperm injection, blastocyst culture, trophectoderm biopsy, time-lapse monitoring, and next-generation sequencing were performed.

Results

After adjusting for patient- and cycle-related factors, six morphokinetic parameters (t5, P = 0.006; t8, P = 0.048; tSB, P < 0.001; tB,P < 0

SUBMITTER: Si K 

PROVIDER: S-EPMC11647804 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature