Establishment of prognostic risk model related to disulfidptosis and immune infiltration in hepatocellular carcinoma.

ABSTRACT:

Background

Disulfidptosis is a newly discovered type of cell death. We aim to identify hub genes associated with both disulfidptosis and immune infiltration in hepatocellular carcinoma (HCC) patients, and to develop an individualized risk prediction model.

Methods

The TCGA-LIHC cohort was utilized as the training set to identify molecular subtypes associated with disulfidptosis and to perform immune infiltration analysis. WGCNA, univariate Cox, and LASSO algorithm were employed to select hub genes for constructing the prognostic model. ICGC-LIRI cohort was utilized as an independent testing set. Validation of the expression of hub genes was performed in vitro using qRT-PCR and Western blot.

Results

Cluster 1 was identified as the disulfidptosis associated molec

SUBMITTER: Xu Z 

PROVIDER: S-EPMC11647807 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature