Molecular diagnostics using the QIAstat-Dx syndromic device for covering avian influenza pandemic preparedness.

ABSTRACT:

Introduction

A key factor in influenza pandemic preparedness is the ability to detect zoonotic influenza virus strains as they emerge in humans through spillover events, ideally before human-to-human transmission occurs.

Design

In this study, the utility of the QIAstat-Dx syndromic device for influenza surveillance was evaluated. Bioinformatic analysis was performed on all WHO-recommended influenza Candidate Vaccine Viruses (CVVs), including the common strains recommended for the 2023-2024 influenza vaccine composition in the northern hemisphere, and 16 different H5 highly pathogenic avian influenza virus (HPAIV) and two H9N2 low pathogenic avian influenza virus (LPAIV) strains. For laboratory validation, engineered gene fragments and real HPAIV and LPAIV samples were tested

SUBMITTER: Penarrubia L 

PROVIDER: S-EPMC11647833 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature