Health-related quality of life assessment in head and neck cancer: A systematic review of phase II and III clinical trials.

ABSTRACT:

Background

Patients with head and neck cancer (HNC) bear a significant load, due to both disease-related symptoms and to toxicities associated with treatments. Evaluating quality of life (QoL) is crucial to gauge the physical and psychological impact on these patients. Our primary aim was to assess whether QoL has been incorporated as an endpoint in phase II and III clinical trials for HNC patients in the last 15 years.

Material and methods

We investigated publications from 11 major journals to identify randomized and non-randomized phase II and phase III clinical trials assessing locoregional and systemic treatments as either single or multimodal strategies, published from 2008 to March 2023 in patients with HNC.

Results

We screened 2045 studies and we selected 158 a

SUBMITTER: Filippini DM 

PROVIDER: S-EPMC11647859 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature