Unlocking the power of multi-institutional data: Integrating and harmonizing genomic data across institutions.

ABSTRACT: Cancer is a complex disease driven by genomic alterations, and tumor sequencing is becoming a mainstay of clinical care for cancer patients. The emergence of multi-institution sequencing data presents a powerful resource for learning real-world evidence to enhance precision oncology. GENIE BPC, led by American Association for Cancer Research, establishes a unique database linking genomic data with clinical information for patients treated at multiple cancer centers. However, leveraging sequencing data from multiple institutions presents significant challenges. Variability in gene panels can lead to loss of information when analyses focus on genes common across panels. Additionally, differences in sequencing techniques and patient heterogeneity across institutions add complexity. High data

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11647914 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature