Cumulative Socioeconomic Status Risk is Associated With Greater Increase in Serum Neurofilament Light Chain Levels Among Middle-Aged Black Adults.

ABSTRACT:

Background

This study examined the longitudinal relationship between cumulative socioeconomic status (SES) risk and serum neurofilament light chain (NfL) levels to better understand the association between social factors and a biomarker of neurodegeneration.

Methods

We used data from the Family and Community Health Study, collecting psychosocial and blood data at 2 waves (2008) and (2019) from 254 Black Americans (43 males and 211 females). Blood samples were analyzed at each wave for serum NfL concentrations. Regression analysis and mixed-effect modeling examined relationships between cumulative SES risk and serum NfL, controlling for covariates and assessing time effects.

Results

Utilizing 11-year longitudinal data, serum NfL levels increased with age. Higher cumula

SUBMITTER: Lei MK 

PROVIDER: S-EPMC11647934 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature