The baseline fecal microbiome differs in patients with and without anastomotic leakage after colorectal cancer surgery.

ABSTRACT:

Background

Anastomotic leakage (AL) is a severe complication of colorectal surgery. The risk of AL is affected by both surgery and patient factors. Gut microbiomes can be generated from the residual material from the fecal immunochemical test (FIT). We, therefore, examined if AL after colorectal cancer surgery could be associated with specific baseline microbiomes in the FIT screening sampling tubes collected weeks before surgery.

Methods

Samples from patients participating in the Danish colorectal cancer screening program were biobanked from 2016 to 2018, and samples from patients who had surgery for screening-detected cancer were included. They were matched with patients without AL in a 1:2 ratio based on age, sex, location of anastomosis (colonic/rectal), ASA classificati

SUBMITTER: Jorgensen AB 

PROVIDER: S-EPMC11647948 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature