Medication Use and Treatment Indications in Huntington's Disease; Analyses from a Large Cohort.

ABSTRACT:

Background

Huntington's Disease is a rare neurodegenerative disorder in which appropriate medication management is essential. While many medications are prescribed based on expert knowledge, overviews of actual medication use in HD are sparse.

Objectives

We provide a detailed overview of medication use and associated indications across HD disease stages, considering sex and regional differences.

Methods

Data from the largest observational HD study, ENROLL-HD, were used. We created HD-related medication and indication classes to identify medication trends in manifest, premanifest and control subjects. We studied medication use in adult, childhood- and adolescent-onset HD, incorporating disease stage (including phenoconverters), sex and regional differences.

Results<

SUBMITTER: Feleus S 

PROVIDER: S-EPMC11647978 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature