Unveiling the Dominant Factors in Subthalamic Stimulation for Improving Depression in Parkinson's Disease.

ABSTRACT:

Background

Currently, the conclusions of studies on subthalamic nucleus (STN) deep brain stimulation (DBS) for improving Parkinson's disease (PD) with depression are inconsistent, and the reasons for improvement or deterioration remain unclear.

Methods

The aim was to investigate the prognosis of PD with depression after bilateral STN-DBS and the factors related to the improvement in depression. The local and network effects of DBS on depression in PD (DPD) were further explored based on the volume of tissue activation (VTA). The study analyzed 80 primary PD patients who had undergone bilateral STN-DBS, comprising 47 patients with improved depression and 33 patients without improvement. Two groups of clinical profiles and stimulation parameters were compared, and the network

SUBMITTER: Zhao G 

PROVIDER: S-EPMC11647981 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature